Situated within a 7-km distance of the Hellenistic Theatre and only 150 metres from Megisti Port, the 3-star Karnayo Hotel Megisti features an archaeological museum.

The centre of Megisti can be reached in 5 minutes' walk of the guest house, and such cultural venues as the Popular Art Museum are approximately a 5-minute drive away. Standing merely 0.7 km from the Blue Grotto, this Megisti hotel is just 1.7 km from the ancient Palaiokastro of Kastelorizo Acropolis. For those travelling from afar, Kastelorizo Island Public airport is 5 minutes' drive away.

The rooms have air conditioning, as well as coffee and tea making equipment for your convenience. Offering such amenities as hairdryers and towels, the bathrooms also include a separate toilet and a shower.

In the immediate vicinity of the Karnayo Megisti, Lazarakis serves Greek meals.